elevated both PT and ApTT

A 9 year old boy with elevated both PT and ApTT. What is the

diagnosis?

1. Defect in extrinsic pathway

2. Defect in Intrinsic pathway

3. Platelet function defect

4. Defect in common pathway

The partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT or APTT) is a performance indicator measuring the efficacy of both the "intrinsic" (now referred to as the contact activation pathway) and the common coagulation pathways

it is also used to monitor the treatment effects with heparin, a major anticoagulant.

It is used in conjunction with the prothrombin time (PT) which measures the extrinsic pathway. Kaolin cephalin clotting time (KccT) is a historic name for the activated partial thromboplastin time

The prothrombin time (PT) and its derived measures of prothrombin ratio (PR) andinternational normalised ratio (INR) are measures of the extrinsic pathway of coagulation. They are used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage, and vitamin K status. PT measures factors I, II, V, VII,